Nestled in the heart of San Francisco, Little Italy—also known as North Beach—is a vibrant neighborhood brimming with culinary delights. From traditional Italian trattorias to modern eateries, this historic area offers something for every palate. Here’s a guide to some of the Best restaurants in little italy san francisco you must try in Little Italy, San Francisco. When it comes to pizza, Tony’s Pizza Napoletana is a must-visit. Helmed by 13-time World Pizza Champion Tony Gemignani, this spot is renowned for its authentic Neapolitan-style pizzas baked in a wood-fired oven.